|
Neural Tube Defects
|
0.340 |
GeneticVariation
|
group |
BEFREE |
We reviewed the literature for ZIC2-ZIC5 deletions and their involvement in neural tube defects (NTDs).
|
21496007 |
2012 |
|
Neural Tube Defects
|
0.340 |
Biomarker
|
group |
CTD_human |
Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.
|
15136147 |
2004 |
|
Neural Tube Defects
|
0.340 |
GeneticVariation
|
group |
BEFREE |
The study focused on the associated brain malformations, including neuronal migration defects, which predominated in individuals with ZIC2 mutations, and neural tube defects, which were frequently associated with ZIC2 (rachischisis) and TGIF mutations.
|
21940735 |
2011 |
|
Neural Tube Defects
|
0.340 |
GeneticVariation
|
group |
BEFREE |
Transmission disequilibrium testing of a frequent polymorphism in the ZIC2 gene (1059C > T, H353H) in parent-spina bifida aperta child triads showed no association with NTD.
|
14679585 |
2004 |
|
Neural Tube Defects
|
0.340 |
GeneticVariation
|
group |
BEFREE |
If this association is confirmed, subtle alterations in ZIC2 activity may confer a risk of NTD.
|
11857562 |
2002 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Integrative molecular concept modeling of prostate cancer progression.
|
17173048 |
2007 |
|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Congenital Abnormality
|
0.050 |
Biomarker
|
group |
BEFREE |
ZIC5 is also located close to ZIC2 in humans, and deletions of 13q32, where ZIC2 is located, lead to congenital brain and digit malformations known as the "13q32 deletion syndrome".
|
15136147 |
2004 |
|
Congenital Abnormality
|
0.050 |
GeneticVariation
|
group |
BEFREE |
In previous studies, we showed that the homozygous Zic1 null mutation (Zic1-/-) results in cerebellar malformation with severe ataxia and that holoprosencephaly and spina bifida occur in homozygotes for Zic2 knockdown mutation (Zic2kd/kd).
|
11699604 |
2001 |
|
Congenital Abnormality
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Mutation in human ZIC2, a zinc finger protein homologous to Drosophila odd-paired, causes holoprosencephaly (HPE), which is a common, severe malformation of the brain in humans.
|
10677508 |
2000 |
|
Congenital Abnormality
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Using samples from a population-based birth defects registry in California, we performed a mutational analysis of the known HPE genes Sonic Hedgehog (SHH), ZIC2, and SIX3, in addition to two HPE candidate genes, TG-interacting factor (TGIF), and Patched (PTC), on a group of sporadic HPE patients.
|
10710230 |
2000 |
|
Congenital Abnormality
|
0.050 |
GeneticVariation
|
group |
BEFREE |
All the foetuses had severe cerebral midline malformations associated with a deletion including the ZIC2 gene.
|
19022413 |
2009 |
|
Congenital anomaly of brain
|
0.050 |
Biomarker
|
group |
BEFREE |
Haploinsufficiency for ZIC2 is likely to cause the brain malformations seen in 13q deletion patients.
|
9771712 |
1998 |
|
Congenital anomaly of brain
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Zic5 is located near Zic2, which is responsible for human brain malformation syndrome (holoprosencephaly, or HPE).
|
15136147 |
2004 |
|
Congenital anomaly of brain
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Patients with mutation in the ZIC2 gene usually present a normal or mildly dysmorphic face associated with a severe brain malformation.
|
24677696 |
2014 |
|
Congenital anomaly of brain
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Studies in the mouse models have suggested that over expression of ZIC2 may also lead to brain malformations.
|
22105922 |
2012 |
|
Congenital anomaly of brain
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Heterozygous loss-of-function mutations in ZIC2 result in the severe brain malformation known as holoprosencephaly (HPE), indicating that forebrain development is exquisitely sensitive to the activity of this poorly understood transcription factor.
|
15590697 |
2005 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The prognostic value of ZIC2 proved to be independent from established clinicopathological variables including Gleason grade, tumour stage, nodal stage and prostate-specific-antigen.
|
31640781 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Additional analysis of 18 sporadic medulloblastomas revealed an overall correlation between highly methylated tumors and poor clinical outcome and identified ZIC2 as a frequently methylated gene in pediatric medulloblastoma.
|
17344319 |
2007 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Zic2 promotes tumor growth and metastasis via PAK4 in hepatocellular carcinoma.
|
28577975 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
ZIC2 expression was about 40-fold in terms of mRNA and about 17-fold in terms of protein in MAL (n = 193) versus LMP (n = 39) tumors.
|
22733541 |
2012 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our data showed that Zic2 expression gradually increased from normal to cancer to metastatic tissues.
|
28577975 |
2017 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The mRNA and protein expression levels of ZIC1 were both found to be significantly decreased in the GC tissues compared to matched normal mucosa tissues (GC vs. normal, 2.15±0.69 vs. 4.28±0.95; P<0.001); however, ZIC2-5 expression exhibited no significant difference between the cancer and normal tissue samples.
|
27177248 |
2016 |
|
Deformity
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In previous studies, we showed that the homozygous Zic1 null mutation (Zic1-/-) results in cerebellar malformation with severe ataxia and that holoprosencephaly and spina bifida occur in homozygotes for Zic2 knockdown mutation (Zic2kd/kd).
|
11699604 |
2001 |
|
Deformity
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Mutation in human ZIC2, a zinc finger protein homologous to Drosophila odd-paired, causes holoprosencephaly (HPE), which is a common, severe malformation of the brain in humans.
|
10677508 |
2000 |